Adam O
Posted by

£211,000 grant awarded for research into incurable form of blood cancer

Adam O
Posted by
03 Jun 2014

Scientists at the University of Southampton are investigating how an incurable type of cancer develops, thanks to a £211,000 grant from Leukaemia & Lymphoma Research.

Dr Surinder Sahota, Reader in Immunogenetics at the University of Southampton, will lead the three-year project. It is hoped the research will further the understanding of disease evolution, assist diagnosis and help develop new drugs for multiple myeloma, a blood cancer that is currently very hard to treat.

Myeloma is a cancer that affects plasma cells and can cause bone pain and damage, together with other debilitating symptoms if not treated. Plasma cells are a specialised type of white blood cell that is normally responsible for producing antibodies as part of the body’s reaction to infection.

The researchers will use next generation DNA sequencing technology to analyse samples of cancer cells from certain myeloma patients. This will allow them to read the more than 20,000 genes in each individual myeloma cell to discover genetic faults that contribute to the onset or development of the disease. From patient to patient, it is known that different myelomas can contain very different genetic abnormalities and this can affect response to treatment.

Even within a patient, different myeloma cells gain different genetic profiles as the disease evolves, which means some treatments may work against only part of the cancer.

Dr Sahota said: “This project seeks to define specific genetic errors in a particular subset of multiple myeloma patients who we know have a poor prognosis. We need to identify the common genetic mistakes that are crucial to driving the cancer in these patients and to understand how the disease evolves over time.”

Dr Matt Kaiser, Head of Research at Leukaemia & Lymphoma Research, said: “Greater understanding of the biology of how multiple myeloma arises and develops could lead to the creation of new, tailored life-saving drugs to target specific cancerous cells. This kind of precision treatment is desperately needed as there is currently no cure for multiple myeloma.”

Comments

09.06.2014

This is wonderful, wonderful news for myeloma patients and their families. This is such a horrible disease and currently there is no way of putting it into remission for good. I hope the project is an enormous success and helps lead to further understanding and, ulitmately, a treatment/cure for his awful blood cancer. 

Anonymous
10.06.2014

This is the best news Iv'e had all year. I hope the research finds a cure.

Anonymous
10.06.2014

My daughter has Multiple Myloma. This is the best news. I hope they find a cure.

11.06.2014

So do I. One day we will beat myeloma and with research projects like this getting the go ahead here's hoping a breakthrough is made sooner rather than later.