High grade lymphomas usually grow more quickly and aggressively than low grade lymphomas.
The most common type of high-grade non-Hodgkin lymphoma (NHL) is diffuse large B-cell lymphoma (DLBCL). But there are a number of other types, including Burkitt lymphoma and peripheral T-cell lymphoma (PTCL).
Chemotherapy is commonly used to treat NHL, and for people with an early stage disease, this approach can be very effective. People who have later stage NHL usually receive chemotherapy with an added biologic therapy, such as rituximab.
But not all people with NHL respond well to treatment, and many will relapse, so we urgently need to find new ways to treat these groups of people.
We are supporting a portfolio of research into high-grade NHL across the UK. Our research aims to transform the way we diagnose and treat NHL, as well as searching for new treatments and tackling drug resistance.