Developing new immunotherapies for people with MDS

Lead researcher - Professor Ghulam Mufti, Kings College London
Immune dysregulation and genetics of Bone Marrow Failure Syndromes
Amount awarded: £1,677,358
Award start date: 01 Feb 2015
Recruitment start date: 13 Jul 2017
Award duration: 4 years

Kings College Hospital is an international centre of excellence for myelodysplastic syndromes, aplastic anaemia and paroxysmal nocturnal haemoglobinuria, collectively these diseases have many overlapping features and are referred to as Bone Marrow Failure Syndromes. The aim of this programme is to not only identify the genetic abnormalities and immune dysregulation in these diseases, but also correlate the interplay between these two systems in a sequential longitudinal study. We will also create appropriate models that recapitulate the clinical phenotypes of these diseases. We will also identify ways to modulate the immune response and utilise it for the therapeutics of marrow failures.