Developing new immunotherapies for people with MDS
Kings College Hospital is an international centre of excellence for myelodysplastic syndromes, aplastic anaemia and paroxysmal nocturnal haemoglobinuria, collectively these diseases have many overlapping features and are referred to as Bone Marrow Failure Syndromes. The aim of this programme is to not only identify the genetic abnormalities and immune dysregulation in these diseases, but also correlate the interplay between these two systems in a sequential longitudinal study. We will also create appropriate models that recapitulate the clinical phenotypes of these diseases. We will also identify ways to modulate the immune response and utilise it for the therapeutics of marrow failures.