How does genetic damage drive ALL?

Lead researcher - Professor Adele Fielding, University College London
IKZF1 lesions in adult acute lymphoblastic lymphoma - the chicken or the egg?
Amount awarded: £148,596
Award start date: 01 Oct 2016
Award duration: 4 years (48 months)

In this PhD project, Rachel Mitchell is working with Professor Adele Fielding at University College London to investigate the role of a gene, IKZF1, that is often faulty in acute lymphoblastic leukaemia (ALL).

Rachel is looking at samples from people with ALL who are on clinical trials to see if an altered or missing IKZF1 gene affects the outcome of the patient. She will also grow cells in the lab and will add faults to the IKZ1 gene to see how this affects their behaviour to gain a more in-depth understanding of how this gene contributes to ALL.

Finally, in collaboration with the Sanger Centre, Rachel will carry out ‘whole genome sequencing’ which allows the whole genome of a cell to be analysed in detail. She will use this technique to track the IKZF1 gene change during the course of a patient's leukaemia.