Mapping the genetic changes in MPN

Lead researcher - Professor Nick Cross, University of Southampton
The molecular pathogenesis of atypical chronic myeloproliferative neoplasms and related disorders
Amount awarded: £2,613,933
Award start date: 01 Oct 2013
Recruitment start date: 13 Jul 2017
Award duration: 5 years

Leukaemia is fundamentally driven by genetic changes (mutations) that are acquired during the lifetime of an individual. Identification of these changes is critical to understand how leukaemia develops and how it may be treated.  In addition, inherited genetic factors may predispose to particular leukaemia subtypes and influence the course by which the disease develops. We aim to develop a comprehensive understanding of the genetic landscape of atypical chronic myeloproliferative neoplasms and related conditions which, due to their rarity, remain difficult to study and relatively under investigated. We will use state of the art genomic technologies to identify novel genetic changes, asses their significance both biologically and for patients and use this information to develop new diagnostic and therapeutic strategies.