Peripheral T-cell lymphoma (PTCL) is a particularly aggressive and difficult to treat non-Hodgkin lymphoma, which has relatively poor outcomes.
People with PTCL are usually given chemotherapy, but sometimes it continues to grow, or comes back after the treatment has finished.
This trial is looking at two drugs called romidepsin and carfilzomib.
Romidepsin inhibits proteins (enzymes) called histone deacetylases - cells need these enzymes to grow and divide. Drugs that block these enzymes are called histone deacetylase inhibitors, or HDAC inhibitors. Carfilzomib is a type of biological therapy called a proteasome inhibitor that also blocks cancer growth by stoppings signals that cancer cells use to divide and grow.
Researchers want to know if combining romidepsin and carfilzomib could help people with PTCL that has come back, or standard treatment has stopped working for them.
The aims of the trial are to:
- Find the best dose of romidepsin and carfilzomib
- Find out if the combination of romidepsin and carfilzomib can help people with PTCL
- Learn more about the side effects
You may be eligible to join this trial if:
- You have PTCL that has come back or treatment has stopped working
- You are at least 16 years old