Understanding why CLL cells grow and survive

Lead researcher - Professor Chris Pepper, University of Sussex
Targeting NF-kB activation, migration and proliferation signals in CLL
Amount awarded: £645,004
Award start date: 01 Nov 2013
Award duration: 4 years, 9 months (57 months)

We have made significant discoveries about the functional importance of a family of proteins called NF-κB in chronic lymphocytic leukaemia (CLL). We want to exploit this new knowledge to dissect the specific roles that these NF-κB proteins play in the growth, activation, cell homing, survival and the development of drug resistance of CLL cells. This will enable us to develop novel targeted therapeutic strategies to improve patient outcomes for those suffering with this incurable disease.