Professor John ...
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New clinical trial for Hodgkin lymphoma patients

Professor John ...
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05 May 2015

Here at The Christie Hospital, Manchester we are one of a number of sites running a new clinical trial for Hodgkin lymphoma, ECHELON-1, and are looking for newly diagnosed patients to take part. Taking part in the trial may give you access to a trial treatment alongside your standard chemptherapy, and may help us tailor treatment for future patients.

The trial involves an antibody drug conjugate called brentuximab vedotin and will test whether its use standard chemotherapy will also improve outcomes in patients with stages 3 and 4, newly diagnosed classical Hodgkin lymphoma, who have not undergone any previous treatment.

If you would like more information about what the ECHELON-1 trial involves and to find out if you could be eligible to take part, please click here.



This is an absolutely wonderful initiative! I hope that the ECHELON-1 trial is a complete success and that more trials become available in such a way in the future. The more choice patients have the better!


Speaking as a survivor of agressive and relapsing Hodgkins Lymphoma I would welcome anything that means a greater survival rate, maybe also less likely to cause side effects. I notice that ECHELON-1 is going to be used alongside traditional treatments. After an operation to remove the tumour I had a 6 month course of ABVD, but because my lungs had been compromised by the original tumour, there were occasions when the Bleomycin was dropped because of my lung function, and perhaps this treatment will cause less damage to organs.

It is difficult making decisions about treatment, and sometimes things seem straightforward at first (like in my case) but then complications set in. Certainly if I had just been diagnosed I would be happy to take part in a trail, as if people before me had not taken that step then my chances of survival would have been minimal.

Wishing all at the Christie every success with their trail

Louise Smith


A friend of mine sent the link to this site to me. I have Hodgkin’s Lymphoma Stage 4 B diagnosed March 2014 – ABVD 6 Cycles followed by Radiotherapy 40grey over 20 sessions completed Dec 2014. I had to wait 14 weeks for PET scan that showed Lymph nodes in Neck were still infected but a possible post RD glitch. Currently awaiting results of PET last week.
Is it possible to get on one of your trials for HLD please
I live in Southern Ireland and Christie's reputation here is first class


Hi Ian,

Thanks so much for getting in touch. Sorry to hear that the lymph nodes are still infected after your initial rounds of treatment. As you say this may be a glitch and fingers crossed that the most recent PET scan results come back more positive. When do you find out the results?

We're not actually involved in the trial selection process and the ECHELON-1 pilot is, unfortunately, only for patients who have been recently diagnosed and are  yet to start treatment. The best thing to do in the first instance is to get in touch with your current consultant and discuss clinical trial options.

Here's a link to find out more about the clinical trials that we're funding which might also be of interest: