- Blood cancer
- Childhood leukaemia
- Acute lymphoblastic leukaemia (ALL)
- Acute myeloid leukaemia (AML)
- Acute promyelocytic leukaemia (APL)
- Chronic lymphocytic leukaemia (CLL)
- Chronic myeloid leukaemia (CML)
- Chronic myelomonocytic leukaemia (CMML)
- Hairy cell leukaemia (HCL)
- Large granular lymphocytic leukaemia (LGLL)
- Plasma cell leukaemia (PCL)
- T-cell acute lymphoblastic leukaemia (T-ALL)
- Other conditions related to blood cancer
Childhood acute myeloid leukaemia (Ch-AML)
Childhood acute myeloid leukaemia (AML) is a fast-developing type of blood cancer that affects blood-producing cells in the bone marrow.
It's a rare type of childhood leukaemia. Around 100 children a year are diagnosed with AML in the UK.
The information in this section is aimed at adults caring for a child or young person with blood cancer. Teenage Cancer Trust has information designed specifically for young people.
Adults can also develop AML but the treatment and outlook is different to childhood AML.
What is childhood acute myeloid leukaemia (AML)?
‘Acute’ means it progresses quickly; ‘myeloid’ refers to the type of white blood cell it affects.
As white blood cells are part of the body’s defences, or immune system, AML reduces the body’s ability to defend itself from infection.
In any cancer, including leukaemia, cells begin to develop abnormally. In AML, these abnormal changes take place in the blood stem cells, found in the bone marrow.
Blood stem cells can develop into different types of blood cell including:
- red blood cells
- white blood cells
- lymphocytes (a kind of white blood cell)
Usually, the stem cells make as many blood cells as we need to stay healthy. Blood cells don’t live very long – between a few hours to around three months – so we need our stem cells to create a constant supply of new ones.
In AML, this efficient system goes wrong. The stem cells start to produce too many blood cells, too quickly. These cells, known as blast cells, are immature; because they aren’t fully developed, they can’t do the job they were made for and they don’t die when they should.
Instead, these cells build up in the bone marrow and spread into the bloodstream. They can be carried by the blood to other areas of the body where they can interfere with the normal function of other cells.
What causes childhood AML?
You and your family aren’t alone: around 140 young people are affected by AML each year.
AML in children is quite rare. AML is most common in adults, particularly in later life.
Broadly speaking, boys and girls are affected equally by AML.
AML isn’t passed from parent to child. It’s rare for a family to have more than one generation affected by AML.
Other risks and causes
There’s nothing you could have done to have prevented your child from developing this condition. In most cases, we don’t know what causes AML, although the following situations may be linked with an increased risk:
- receiving anti-cancer drugs to treat other forms of cancer – known as therapy-related AML; this rarely affects children
- having Down’s syndrome: children with this condition are more likely to develop a particular type of AML.