Finding better ways to diagnose and personalise treatments for people with PTCL

Lead researcher - Dr Matthew Ahearne, University of Leicester
Genetic markers from circulating DNA in PTCL - a RomiCar trial sub-study
Amount awarded: £12,847
Award start date: 01 Mar 2016
Award duration: 3 years (36 months)

Peripheral T-cell lymphoma (PTCL) is a rare type of non-Hodgkin lymphoma, and happens when something goes wrong with T-cells. Recently, changes in genes driving PTCL have been discovered, which could help with not only diagnosing the disease, but could also be new drug targets.

At the moment, diagnosing PTCL is done through minor surgery where doctors remove a sample of lymphoma cells from an enlarged lymph node. This process can be very painful.

Dr Matthew Ahearne and his team from the University of Leicester want to find a better way of diagnosing and characterising PTCL. They will collect blood samples from people with PTCL who are taking part in the Bloodwise-funded RomiCar trial. The team will develop ways to detect the gene changes that are driving PTCL using these blood samples, which will be the first time this approach has been used.

If successful, their work will provide a less painful way of diagnosing and personalising treatments for people with PTCL.